I ran into a situation where a large VM had its replication enabled, and the initial replication (IR) sent to a USB drive. Then IR was imported on the DR site. Everything was fine but later on, for one reason or another, the replica was deleted. At this point you have the option of recreating another IR to a USB drive, sending that USB drive to your DR site, importing the new IR again. All that, of course, will take quite a lot of time.
The alternative is to import the same old IR on the USB drive (assuming it is still there at the DR site) and letting the replication sync up the changed bits.
Here is how to do that.